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Search Results for " s-phase protein "

Targets Recommended: Apoptosis IAP Caspase Topoisomerase p53

8

抑制剂 & 化合物

2

天然产物

1

化合物库

18

重组蛋白

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Cat. No.	Product Name
L8100	细胞周期化合物库		677 compounds
	677 种细胞周期相关的生物活性小分子化合物的特有集合，用于高通量、高内涵筛选；

化合物库

细胞周期化合物库

Cat.No: L8100

Compounds: 677

Cat. No.	Product Name	Target	Signaling Pathways
T16522	Phenoxodiol 脱氢雌马酚,Dehydroequol,Idronoxil,Haginin E	Apoptosis; IAP; Caspase; Topoisomerase; p53	Apoptosis; DNA Damage/DNA Repair; Proteases/Proteasome
	Phenoxodiol (Idronoxil) 是合成genestein 的类似物，激活线粒体caspase 系统，抑制XIAP，使癌细胞对fas 介导的凋亡敏感。它在细胞周期的G1/S 期诱导细胞周期阻滞，通过独立于p53的方式上调p21WAF1。它通过稳定可分裂复合物抑制DNA 拓扑异构酶II，从而阻止DNA 复制。
T77697	BML-278 BML278,BML 278	Sirtuin; Histone Methyltransferase	Chromatin/Epigenetic; DNA Damage/DNA Repair
	BML-278 是一种 SIRT1 激活剂，EC150 值为 1 μM。BML-278 增加父本和母本原核中的 H3K9 甲基化并抑制 H3K9 乙酰化，可用于改善早期胚胎发育。BML-278 促使原代人间充质细胞的细胞周期停止在 G1/S 期，可用于延缓衰老。BML-278 减少 U937 细胞中的微管蛋白乙酰化，增加小鼠 C2C12 成肌细胞的线粒体密度。
T33380	MI-389	PROTACs	PROTAC
	MI-389 is a protein degrader, targeting the translation termination factor G1 to S phase transition 1 (GSPT1).
T78194	Skp2 inhibitor 2	E1/E2/E3 Enzyme	Ubiquitination
	Skp2 inhibitor 2 (14f)为F-box蛋白S期激酶相关蛋白2（Skp2）的抑制剂，其IC50值为10.2 μM（针对Skp2-Cks1复合体）。该化合物是cullin-RING 连接酶的组成部分，负责招募并使底物泛素化，从而涉及蛋白质的水解和非水解相关过程。
T62835	Antitumor agent-54
	Antitumor agent-54 (Compound C11) 是一种 14-3-3η 蛋白抑制剂 (KD: 35 μM)。Antitumor agent-54 能够抑制几种典型的人肝癌细胞系。Antitumor agent-54 可以将细胞周期阻滞在 G1-S 期，并诱导细胞凋亡，表现出良好的代谢稳定性。
T36894	5-Bromouridine
	5-Bromouridine is a brominated analog of the nucleoside uridine .1It can be incorporated into RNA and subsequently detected by antibodies against bromodeoxyuridine .25-Bromouridine decreases the viability of HL-60 and MOLT-4 cells (LC50s = 10 and 20 μM, respectively). It induces apoptosis and halts the cell cycle at the S phase in HL-60 cells. It is photoreactive, and UV irradiation has been used to cross-link RNA containing 5-bromouridine to proteins in the study of of RNA-protein interactions....
T83886	icFSP1 TFA
	icFSP1是一种抑制剂，针对的是铁死亡抑制蛋白1（FSP1）。在2.5 µM的浓度下使用时，能够引发FSP1在细胞中的凝聚和相分离，但在无细胞测试中并不抑制FSP1的酶活性（IC50 = > 30 µM）。icFSP1以浓度依赖的方式诱导HT-1080纤维肉瘤细胞的铁死亡。在体内，icFSP1（50 mg/kg）通过使用人类过表达FSP1，Gpx4-/-Fsp1-/-的B16/F10细胞，在B16/F10鼠黑色素瘤模型中减少肿瘤体积和重量。
T36717	RWJ-56110 dihydrochloride
	RWJ-56110 dihydrochloride is a potent, selective, peptide-mimetic inhibitor of PAR-1 activation and internalization (binding IC50=0.44 uM) and shows no effect on PAR-2, PAR-3, or PAR-4. RWJ-56110 dihydrochloride inhibits the aggregation of human platelets induced by both SFLLRN-NH2 (IC50=0.16 μM) and thrombin (IC50=0.34 μM), quite selective relative to U46619 . RWJ-56110 dihydrochloride blocks angiogenesis and blocks the formation of new vessels in vivo. RWJ-56110 dihydrochloride induces cell ap...

化合物

Cat.No: T16522

Synonym: 脱氢雌马酚,Dehydroequol,Idronoxil,Haginin E

Target: Apoptosis, IAP, Caspase, Topoisomerase, p53

Cat.No: T77697

Synonym: BML278,BML 278

Target: Sirtuin, Histone Methyltransferase

Cat.No: T33380

Target: PROTACs

Skp2 inhibitor 2

Cat.No: T78194

Target: E1/E2/E3 Enzyme

Antitumor agent-54

Cat.No: T62835

Cat.No: T36894

Cat.No: T83886

RWJ-56110 dihydrochloride

Cat.No: T36717

Cat. No.	Product Name	Target	Signaling Pathways
TN5264	Xanthoxyletin	TNF; NOS; ROS; COX; Antifection	Apoptosis; Immunology/Inflammation; Microbiology/Virology; Neuroscience
	Xanthoxyletin shows potent antibacterial, fungicidal, and algicidal properties, it also has anticancer, and anti-inflammatory activities. It shows an inhibitory effect on iNOS protein expression at 10 microM, it also can inhibit the synthesis of nitric oxide and the protein expression of tumor necrosis factor-alpha and cyclooxygenase-2. Xanthoxyletin induces S phase arrest and apoptosis in human gastric adenocarcinoma SGC-7901 cells, the effects are associated with the DNA damage, apoptosis thro...
T36954	Nemorosone
	Nemorosone is a polycyclic polyprenylated acylphloroglucinol (PPAP) originally isolated from C. rosea that has antiproliferative properties.1 Nemorosone inhibits growth of NB69, Kelly, SK-N-AS, and LAN-1 neuroblastoma cells (IC50s = 3.1-6.3 μM), including several drug-resistant clones, but not MRC-5 human embryonic fibroblasts (IC50 = >40 μM).2 It increases DNA fragmentation in LAN-1 cells in a dose-dependent manner, and decreases N-Myc protein levels and phosphorylation of ERK1/2 by MEK1/2. Nem...

天然产物

Cat.No: TN5264

Target: TNF, NOS, ROS, COX, Antifection

Cat.No: T36954

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-05642	SKP1 Protein, Human, Recombinant (His & Avi), Biotinylated S-phase kinase-ass	Human	E. coli
	SKP1 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in E. coli expression system with His and Avi tag. The predicted molecular weight is 22 kDa and the accession number is P63208.
TMPH-01733	DDAH2 Protein, Human, Recombinant (GST & His) Inactive dimethylarginine dimethylaminohydrolase 2,...	Human	E. coli
	Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation. DDAH2 Protein, Human, Recombinant (GST & His) is expressed in E. coli expression system with N-6xHis-GST tag. The predicted molecular weight is 61.2 kDa and the accession number is O95865.
TMPY-04548	CDK4 Protein, Human, Recombinant (GST) CMM3,PSK-J3,cyclin-dependent kinase 4	Human	Baculovirus Insect Cells
	CDK4 is a member of the Ser/Thr protein kinase family. It is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of CDK4 is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). CDK4 was shown to be responsible for the phosphorylation of retinoblastoma gene product. CDK4 is the ser...
TMPY-04542	CDK2 Protein, Human, Recombinant (His) CDKN2,cyclin-dependent kinase 2,p33(CDK2)	Human	Baculovirus Insect Cells
	CDK2 is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. Cdks (cyclin-dependent kinases) are heteromeric serine/threonine kinases that control progression through the cell cycle in concert with their regulatory subunits, the c...
TMPK-00016	Cpn10/HSPE1 Protein, Human/Mouse/Goat, Recombinant (His & Avi), Biotinylated Hsp10,Chaperonin 10,HSPE1,GROES,E...	Human,Mouse,Goat	E. coli
	Cpn10/HSPE, a 10-kDa heat shock protein, is a novel interacting partner of NPAT. A pool of Cpn10 is colocalized with NPAT foci during G1 and S phases in nuclei.Cpn10 is important for S phase progression and cell proliferation. Interaction of Heat Shock Protein Cpn10 with the Cyclin E/Cdk2 Substrate Nuclear Protein Ataxia-Telangiectasia (NPAT) Is Involved in Regulating Histone Transcription. Cpn10/HSPE1 Protein, Human/Mouse/Goat, Recombinant (His & Avi), Biotinylated is expressed in E. coli expre...
TMPK-00015	Cpn10/HSPE1 Protein, Human/Mouse/Goat, Recombinant (His & Avi) GROES,Hsp10,Chaperonin 10,HSPE1,E...	Human,Mouse,Goat	E. coli
	Cpn10/HSPE, a 10-kDa heat shock protein, is a novel interacting partner of NPAT. A pool of Cpn10 is colocalized with NPAT foci during G1 and S phases in nuclei.Cpn10 is important for S phase progression and cell proliferation. Interaction of Heat Shock Protein Cpn10 with the Cyclin E/Cdk2 Substrate Nuclear Protein Ataxia-Telangiectasia (NPAT) Is Involved in Regulating Histone Transcription. Cpn10/HSPE1 Protein, Human/Mouse/Goat, Recombinant (His & Avi) is expressed in E. coli expression system w...
TMPK-00044	SKP1 Protein, Human, Recombinant (His, Avi) OCP-II,TCEB1L,SIII,p19A,OCP-2,EMC19,OCP2,S...	Human	HEK293 Cells
	The S-phase Kinase-Associated Protein 1 (SKP1) is a core component of the SKP1, Cullin 1, F-box protein (SCF) complex, an E3 ubiquitin ligase that serves to poly-ubiquitinate a vast array of protein targets as a signal for their proteasomal degradation, thereby playing a critical role in the regulation of downstream biological processes. SKP1 Protein, Human, Recombinant (His, Avi) is expressed in HEK293 mammalian cells with N-His and C-Avi tag. The predicted molecular weight is 21.43 kDa and the...
TMPK-00045	SKP1 Protein, Human, Recombinant (His, Avi), Biotinylated SIII,OCP-2,TCEB1L,EMC19,OCP-II,OCP2,SKP1A,...	Human	HEK293 Cells
	The S-phase Kinase-Associated Protein 1 (SKP1) is a core component of the SKP1, Cullin 1, F-box protein (SCF) complex, an E3 ubiquitin ligase that serves to poly-ubiquitinate a vast array of protein targets as a signal for their proteasomal degradation, thereby playing a critical role in the regulation of downstream biological processes. SKP1 Protein, Human, Recombinant (His, Avi), Biotinylated is expressed in HEK293 mammalian cells with N-His and C-Avi tag. The predicted molecular weight is 21....
TMPJ-00721	ZBED1 Protein, Human, Recombinant (His) TRAMP,dREF Homolog,ALTE,DREF,ZBED1,Zinc Finger BED Domain-Co...	Human	E. coli
	Zinc Finger BED Domain-Containing Protein 1 (ZBED1) contains one BED-type zinc finger and is found in the cell nucleus. ZBED1 is widely expressed, highly in heart, skeletal muscle, spleen and placenta. The expression of ZBED1 is usually linked to the cell cycle. During the G1/S phase, the expression is increasing. During the S/G2 phage, the expression reaches to the highest, and then decreasing. ZBED1 exists in homodimer forms, which can bind to 5’-TGTCCG[CT]GA[CT]A-3’ DNA elements, that can be ...
TMPJ-00053	PRL-2 Protein, Human, Recombinant (His) HU-PP-1,Protein tyrosine phosphat...	Human	E. coli
	PTP4A2, also known as PRL2 or PTPCAAX2, is short for Protein tyrosine phosphatase type IVA 2. This protein exists in cell membrane, cytoplasm,endosome and membrane. PTP4A2 is often farnesylated during post-translational modification. Farnesylation is required for membrane targeting and for interaction with RABGGTB. The unfarnesylated forms are redirected to the nucleus and cytosol. It can stimulate progression from G1 into S phase during mitosis and promotes tumors. It also inhibits geranylgeran...
TMPJ-00907	GADD45A Protein, Human, Recombinant (His) GADD45,DDIT1,Growth Arrest and DNA Damage-Inducible...	Human	E. coli
	Growth Arrest and DNA Damage-Inducible Protein GADD45 α (GADD45A) is a member of the GADD45 family. GADD45A can be induced by UV irradiation, X-rays, growth arrest and alkylating agents, of which can be mediated by some kinases other than PKC. GADD45A can interact with MAPK14, GADD45GIP1, PCNA. In T-cells, GADD45A functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity. GADD45A may affect PCNA interaction with some cell division protein kinase complexes, stimulating ...
TMPJ-01241	DTD1 Protein, Human, Recombinant (His) DUE-B,D-tyrosyl-tRNA(Tyr) deacylase 1,DNA-...	Human	HEK293 Cells
	D-tyrosyl-tRNA(Tyr) deacylase 1(DTD1) belongs to the DTD family, and expressed in many adult and fetal tissues such as testis, ovary, spleen in adult and fetal brain. It is a nucleus and cytoplasm located protein, and is preferentially phosphorylated in cells arrested early in S phase. DTD1 is an ATPase involved in DNA replication, it may facilitate loading of CDC45 onto pre-replication complexes. The protein may hydrolyze D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr), a possible defens...
TMPY-02543	PCNA Protein, Human, Recombinant (His) ATLD2,proliferating cell nuclear antigen	Human	Baculovirus Insect Cells
	Proliferating Cell Nuclear Antigen (PCNA) is a protein only expressed in normal proliferate cells and cancer cells. It is central to both DNA replication and repair. One of the well-established functions for PCNA is its role as the processivity factor for DNA polymerase delta and epsilon. PCNA tethers the polymerase catalytic unit to the DNA template for rapid and processive DNA synthesis. Two forms of PCNA exist in cells: (i) a detergent-insoluble trimeric form stably associated with the replic...
TMPY-03603	AHSP Protein, Human, Recombinant ERAF,alpha hemoglobin stabilizing protein,...	Human	E. coli
	AHSP, also known as ERAF, is a conserved mammalian erythroid protein which belongs to the AHSP family. It is expressed in blood and bone marrow. AHSP facilitates the production of Hemoglobin A by stabilizing free α-globin. It rapidly binds to ferrous α with association (k'(AHSP)) and dissociation (k(AHSP)) rate constants of ≈1 μm(-1) s(-1) and .2 s(-1), respectively, at pH 7.4 at 22 ℃. A small slow phase was observed when AHSP binds to excess ferrous αCO. This slow phase appears to be due to cis...
TMPJ-00769	TK1 Protein, Human, Recombinant (His) cytosolic,Thymidine kinase,TK1	Human	HEK293 Cells
	Thymidine kinase 1(TK1) belongs to the thymidine kinase family. It is located in the cytoplasm, and phosphorylated on Ser-13 in mitosis during post-translational modification. Two forms of this protein have been identified in animal cells, one in cytosol TK1 and one in mitochondria TK2. Thymidine kinases have a key function in the synthesis of DNA and thereby in cell division, as they are part of the unique reaction chain to introduce deoxythymidine into the DNA. Activity of the cytosolic enzyme...
TMPJ-00936	CCND2 Protein, Human, Recombinant (His) G1/S-specific cyclin-D2,CCND2	Human	E. coli
	CCND2，also known as G1/S-specific cyclin-D2，is a member of the highly conserved cyclin family. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Cyclins function as regulators of CDK kinases. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. CCND2 is involved in a number of fundamental biological processes such ...
TMPY-02402	WTAP Protein, Human, Recombinant (GST) Mum2,Wilms tumor 1 associated	Human	E. coli
	Wilms' tumor 1-associating protein (WTAP) was previously identified as a protein associated with Wilms' tumor-1 (WT-1) protein that is essential for the development of the genitourinary system. WT1 was originally identified as a tumor suppressor for Wilms' tumor, but it is also overexpressed in a variety of cancer cells. The WTAP-WT1 axis in vascular cells suggest that WTAP is a vital and multifaceted regulator of vascular remodeling. WTAP has been suggested to function in alternative splicing, ...
TMPY-01401	Cyclin A1 Protein, Human, Recombinant (His) cyclin A1,CT146	Human	Baculovirus Insect Cells
	Cyclin A1 is a member of the highly conserved cyclin family that is characterized by a dramatic periodicity in protein abundance, and belongs to the A-type cyclin subfamily. The mammalian A-type cyclin family consists of two members: cyclin A1 and cyclin A2. Different cyclins exhibit distinct expression. Cyclin A1 is expressed in mice exclusively in the germ cell lineage and high rate of cyclinA1 is found in human testis and certain myeloid leukaemia cells. Cyclin A1 is primarily function in the...

重组蛋白

SKP1 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPY-05642

Species: Human

Expression System: E. coli

DDAH2 Protein, Human, Recombinant (GST & His)

Cat.No: TMPH-01733

Species: Human

Expression System: E. coli

CDK4 Protein, Human, Recombinant (GST)

Cat.No: TMPY-04548

Species: Human

Expression System: Baculovirus Insect Cells

CDK2 Protein, Human, Recombinant (His)

Cat.No: TMPY-04542

Species: Human

Expression System: Baculovirus Insect Cells

Cpn10/HSPE1 Protein, Human/Mouse/Goat, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00016

Species: Human,Mouse,Goat

Expression System: E. coli

Cpn10/HSPE1 Protein, Human/Mouse/Goat, Recombinant (His & Avi)

Cat.No: TMPK-00015

Species: Human,Mouse,Goat

Expression System: E. coli

SKP1 Protein, Human, Recombinant (His, Avi)

Cat.No: TMPK-00044

Species: Human

Expression System: HEK293 Cells

SKP1 Protein, Human, Recombinant (His, Avi), Biotinylated

Cat.No: TMPK-00045

Species: Human

Expression System: HEK293 Cells

ZBED1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00721

Species: Human

Expression System: E. coli

PRL-2 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00053

Species: Human

Expression System: E. coli

GADD45A Protein, Human, Recombinant (His)

Cat.No: TMPJ-00907

Species: Human

Expression System: E. coli

DTD1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01241

Species: Human

Expression System: HEK293 Cells

PCNA Protein, Human, Recombinant (His)

Cat.No: TMPY-02543

Species: Human

Expression System: Baculovirus Insect Cells

AHSP Protein, Human, Recombinant

Cat.No: TMPY-03603

Species: Human

Expression System: E. coli

TK1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00769

Species: Human

Expression System: HEK293 Cells

CCND2 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00936

Species: Human

Expression System: E. coli

WTAP Protein, Human, Recombinant (GST)

Cat.No: TMPY-02402

Species: Human

Expression System: E. coli

Cyclin A1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01401

Species: Human

Expression System: Baculovirus Insect Cells

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